Trends Immunol. 2025 Jul 15:S1471-4906(25)00170-X. doi: 10.1016/j.it.2025.07.003. Online ahead of print.
ABSTRACT
Neutrophil numbers fluctuate over time, peaking during active phases to enhance immunity. The molecular link between circadian signals and cellular clocks remains unclear. Yi Du et al. show that light-regulated Per2 increases reactive oxygen species (ROS) production and bacterial killing in zebrafish neutrophils by controlling Hmgb1 expression, highlighting the impact of light on immune function.
PMID:40670204 | DOI:10.1016/j.it.2025.07.003