Trends Immunol. 2025 Jul 18:S1471-4906(25)00173-5. doi: 10.1016/j.it.2025.07.006. Online ahead of print.
ABSTRACT
CD8 T cell activation and acquisition of cytolytic activity, which is essential for adaptive immunity, begins with priming in the lymph node (LN). Jobin et al. recently identified a second, delayed priming phase driven by competition with regulatory T cells for IL-2, revealing a rate-limiting step with significant clinical implications.
PMID:40683779 | DOI:10.1016/j.it.2025.07.006