Homozygosity for the Common IL23R R381Q Variant Associates with Increased Susceptibility to Chronic Mucocutaneous Candidiasis. [[{“value”:”Margaux Gerbaux, Frederik Staels, Mathijs Willemsen, Julika Neumann, Leoni Bücken, Lize Van Meerbeeck, Willem Roosens, Adrian Liston, Stéphanie Humblet‐Baron, Rik Schrijvers”}]]

Chronic mucocutaneous candidiasis can be caused by an Inborn Error of Immunity, especially those affecting TH-17 / IL-17 responses. Through in-depth immunophenotyping and functional assays, we reveal the association between homozygous carriage of the common p.R381Q IL-23R genetic variant and increased candidiasis susceptibility, relying on disrupted IL-23-mediated IL-17 immunity.