J Leukoc Biol. 2025 Jul 22:qiaf106. doi: 10.1093/jleuko/qiaf106. Online ahead of print.
ABSTRACT
Chronic Graft versus Host Disease (cGvHD) is a major late determinant of transplant related mortality (TRM) after allogeneic stem cell transplantation (HSCT). We investigated the predictive value of peripheral blood activated HLA-DR+CD3+ T cells as a novel biomarker. In total, 107 patients were included in this retrospective analysis. Peripheral blood HLA-DR+CD3+ T cells were measured by flow cytometry three months after HSCT. A HLA-DR+CD3+ T cell count <140 cells/μl at month three after HSCT correlated significantly with an increased TRM. A HLA-DR+CD3+ T cell count <100 cells/μl was associated with a higher rate of cGvHD grade 2-3. Subgroup analyses revealed significant results for TRM and cGvHD grade 2-3 for patients with a reduced intensity conditioning (RIC). In summary, low HLA-DR+CD3+ T cells in the peripheral blood three months after HSCT may represent a novel biomarker to identify patients with an increased risk for TRM and cGvHD grade 2-3.
PMID:40694621 | DOI:10.1093/jleuko/qiaf106