Trends Immunol. 2025 Jul 29:S1471-4906(25)00176-0. doi: 10.1016/j.it.2025.07.009. Online ahead of print.
ABSTRACT
Chronic inflammation drives diseases like osteoarthritis and MASH, yet its molecular distinction from acute inflammation remains unclear. In a recent Nature study, Wang et al. revealed that chronic stress triggers WSTF degradation via nuclear autophagy, amplifying NF-κB responses. Blocking this pathway attenuates chronic inflammation while sparing acute immunity.
PMID:40738769 | DOI:10.1016/j.it.2025.07.009