Trends Immunol. 2025 Aug 7:S1471-4906(25)00180-2. doi: 10.1016/j.it.2025.07.013. Online ahead of print.
ABSTRACT
Early antibiotic exposure disrupts the gut microbiota, impairing newborn antiviral immunity. Stevens et al. uncover that inosine, a metabolite produced by gut bacteria, restores the function of antiviral T cells by modulating gene regulation, boosting lung immune defenses against respiratory viruses.
PMID:40781010 | DOI:10.1016/j.it.2025.07.013