Trends Immunol. 2025 Aug 13:S1471-4906(25)00174-7. doi: 10.1016/j.it.2025.07.007. Online ahead of print.
ABSTRACT
An allelic variant of the autophagy gene ATG16L1 (T300A) is a genetic risk factor for Crohn’s disease. However, over 50% of the global population carries at least one copy. Yao et al. have demonstrated a heterozygote advantage, where the pathogen-protective effect of one allele may outweigh the disease risk in homozygotes.
PMID:40813227 | DOI:10.1016/j.it.2025.07.007