Trends Immunol. 2025 Sep 12:S1471-4906(25)00218-2. doi: 10.1016/j.it.2025.08.008. Online ahead of print.
ABSTRACT
Tumor-associated macrophages (TAMs) are key regulators of the tumor microenvironment (TME), but their heterogeneity, driven by tumor-derived cues, poses challenges for therapeutic targeting and underscores the need for precise macrophage reprogramming strategies. Through a genome-wide clustered regularly interspaced short palindromic repeats (CRISPR) screen, Marelli et al. identified chemosensors as lipid-sensing regulators of macrophage activity, revealing new therapeutic avenues.
PMID:40946000 | DOI:10.1016/j.it.2025.08.008