Semin Immunol. 2025 Oct 6;80:101997. doi: 10.1016/j.smim.2025.101997. Online ahead of print.
ABSTRACT
The IL-1 family comprises 11 cytokines, including IL-1α, IL-1β, IL-1 receptor antagonist (IL-1Ra), IL-18, IL-33, and IL-36 cytokines to IL-37 and IL-38, that modulate innate immune system activity. In addition to their role in innate immunity, IL-1 family members can activate and enhance the function of polarized T cells. For example, IL-33 primarily influences T helper 2 (TH2) cells, IL-1 plays a central role in the differentiation of TH17 cells, and IL-18 predominantly affects TH1 cells. The IL-1 family members participated in various biological functions as described elsewhere in this special issue. Here, we provide an overview on IL-18, originally called IFN-γ inducing factor, and its role in impacting cancer immunity.
PMID:41056758 | DOI:10.1016/j.smim.2025.101997