Power to the Tregs in transplantation tolerance in LATAM: From the basics to the bedside. Karina Pino-Lagos

Semin Immunol. 2026 Sep 11;84:102066. doi: 10.1016/j.smim.2026.102066. Online ahead of print. ABSTRACT T regulatory cells (Tregs) come in different flavors, but they all share suppressive function and the role in the generation and maintenance of immune tolerance. Due to this essential activity, Tregs are targets for immunotherapy: Tregs promotion is wanted in pathological conditions such … Read more

IL-1-mediated cancer-adapted hematopoiesis in aging and clonal hematopoiesis. Francisco Caiado

Semin Immunol. 2026 Aug 25;83:102055. doi: 10.1016/j.smim.2026.102055. Online ahead of print. ABSTRACT A defining and evolutionary-selected feature of hematopoiesis is its capacity to adapt to organismal cellular needs. This demand-adapted hematopoiesis relies on a complex peripheric immune system capable of sensing minute amounts of damage and pathogen molecular patterns and trigger an inflammation-based reaction that … Read more

The multifaceted roles of cellular senescence in liver pathophysiology: from tissue repair to tumor progression. Efi Tsouri

Semin Immunol. 2026 Aug 17;83:102053. doi: 10.1016/j.smim.2026.102053. Online ahead of print. ABSTRACT Cellular senescence is a stress-response program that coordinates cell-autonomous growth arrest and non-cell autonomous remodeling of the tissue environment. Initially defined through its role in aging and tumor suppression, senescence is now recognized as a highly complex program shaped by cell-intrinsic and environmental … Read more

The burden of tuberculosis in Latin America: Immunogenetic and socioepidemiological determinants. Mayra Silva-Miranda

Semin Immunol. 2026 Aug 13;83:102054. doi: 10.1016/j.smim.2026.102054. Online ahead of print. ABSTRACT Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a major global health challenge and the leading cause of death from a single infectious agent. Despite diagnostic and therapeutic advances, the COVID-19 pandemic reversed progress in TB control, with a notable rise in incidence … Read more

The IL-1 system in inflammation and cancer. Cecilia Garlanda

Semin Immunol. 2026 Aug 8;83:102051. doi: 10.1016/j.smim.2026.102051. Online ahead of print. ABSTRACT Inflammation is a pathogenetic driver of several pathological conditions, including cancer. The tumor microenvironment, which includes cellular, molecular, and structural components, is an essential component of cancer, involved in tumor promoting or controlling processes. In particular, inflammatory players contribute to the establishment of … Read more

IL-1-driven systemic inflammation in tumour progression and metastatic spread. Jacqueline Alford

Semin Immunol. 2026 Aug 7;83:102052. doi: 10.1016/j.smim.2026.102052. Online ahead of print. ABSTRACT Inflammation is a fundamental immune response that protects against injury and infection; however, when unresolved, it can contribute to disease pathogenesis. Chronic inflammation is a hallmark of cancer that promotes tumour initiation and metastatic spread. Notably, this relationship is bidirectional: while chronic inflammation … Read more

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