Semin Immunol. 2026 Apr 16;82:102026. doi: 10.1016/j.smim.2026.102026. Online ahead of print. ABSTRACT TH9 cells, a distinct subset of CD4+ T helper cells characterized by IL-9 production, have emerged as key players in cancer immunology. Initially recognized for their potent antitumor activity upon adoptive cell transfer against melanoma, recent studies have revealed a more complex and … Read more
Semin Immunol. 2026 Apr 1;82:102025. doi: 10.1016/j.smim.2026.102025. Online ahead of print. ABSTRACT The COVID-19 pandemic had a profound impact on Latin America, exposing structural inequalities, fragmented healthcare systems, and longstanding technological dependence. The region experienced a high burden of infection and excess mortality, influenced by socioeconomic vulnerability and a high prevalence of metabolic comorbidities. In … Read more
Semin Immunol. 2026 Mar;81:102000. doi: 10.1016/j.smim.2025.102000. ABSTRACT Adapting the success of chimeric antigen receptor T cell therapy from hematologic malignancies to solid tumors has become a major focus of ongoing research activities. However, the unique challenges posed by solid tumors, such as limited immune cell infiltration, reduced T cell persistence, and antigen loss, have led … Read more
Semin Immunol. 2026 Feb 24;81:102017. doi: 10.1016/j.smim.2026.102017. Online ahead of print. ABSTRACT Upon antigenic stimulation and cytokine cues, CD4⁺ T cells differentiate into specialized helper subsets, giving rise to Th1, Th2, Th9 and Th17 cell lineages. These subsets orchestrate distinct immune functions that protect the host but can also drive immunopathology when dysregulated. The classical … Read more
Semin Immunol. 2026 Feb 21:102018. doi: 10.1016/j.smim.2026.102018. Online ahead of print. NO ABSTRACT PMID:41723008 | DOI:10.1016/j.smim.2026.102018
Semin Immunol. 2026 Feb 10;81:102016. doi: 10.1016/j.smim.2026.102016. Online ahead of print. ABSTRACT Autoimmune diseases of the central nervous system (CNS), including multiple sclerosis (MS), neuromyelitis optica spectrum disorders (NMOSD), and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), are characterized by chronic inflammation driven by autoreactive immune responses against CNS antigens. Successes in the development of efficacious … Read more
Semin Immunol. 2026 Jan 29;81:102015. doi: 10.1016/j.smim.2026.102015. Online ahead of print. ABSTRACT Recent studies have revealed that neurotransmitters, as a class of important signaling molecules, have functional roles that extend beyond the traditional nervous system and play critical regulatory functions in the tumor immune microenvironment. Research has demonstrated that various classical neurotransmitters and their receptors … Read more
Semin Immunol. 2026 Jan 14;81:102014. doi: 10.1016/j.smim.2026.102014. Online ahead of print. ABSTRACT IL-9 promotes airway hyperresponsiveness, eosinophilia, mast cell expansion, and antibody-mediated inflammation through interactions with mast cells, eosinophils, B cells, and airway and lung macrophages in models of allergic airway disease. IL-9 has increasingly been linked to asthma severity in patients. Early studies primarily … Read more
Semin Immunol. 2025 Dec 16;81:102013. doi: 10.1016/j.smim.2025.102013. Online ahead of print. ABSTRACT The involvement of T helper cells in the pathogenesis of inflammatory bowel diseases (IBD), including Crohn’s disease and ulcerative colitis, has been a subject of considerable research interest. The clinical picture of IBD is characterised by chronic intestinal inflammatory processes that may lead … Read more
Semin Immunol. 2025 Dec 15;81:102012. doi: 10.1016/j.smim.2025.102012. Online ahead of print. ABSTRACT The liver is both a central metabolic organ and a uniquely tolerogenic immune niche, which makes it a frequent site of liver metastases (LMS) and a challenging environment for immunotherapy. It is increasingly appreciated that resident liver cells- Kupffer cells, Ito cells, liver … Read more
