Seminars in Immunology

Semin Immunol. 2026 Jul 24;83:102049. doi: 10.1016/j.smim.2026.102049. Online ahead of print. ABSTRACT Ferroptosis links cellular metabolism to immune regulation. Beyond its role as an iron-dependent form of regulated cell death, ferroptosis generates signals, including oxidized lipids, iron metabolites, and damage-associated molecular patterns, that influence inflammatory and immune responses. The pancreas is particularly susceptible to ferroptotic … Read more

Semin Immunol. 2026 Jul 24;83:102050. doi: 10.1016/j.smim.2026.102050. Online ahead of print. ABSTRACT Interleukin-1β (IL-1β) has long been characterized as a foundational mediator of innate immunity, yet this designation captures only a fraction of its biological significance. A growing body of evidence now positions IL-1β as a molecular arbiter of tissue restoration – a context-sensitive instructor … Read more

Semin Immunol. 2026 Jun 27;83:102048. doi: 10.1016/j.smim.2026.102048. Online ahead of print. ABSTRACT Inflammation is a defining feature of the tumor microenvironment (TME) and a key driver of cancer progression. Among inflammatory mediators, the interleukin-1 (IL-1) family of cytokines serves as a central mediator linking tissue damage, metabolic stress and microbial cues to innate immune activation. … Read more

Semin Immunol. 2026 Jun 15;83:102047. doi: 10.1016/j.smim.2026.102047. Online ahead of print. ABSTRACT Interleukin-1 (IL-1) exerts a pivotal role in the regulation of innate immune responses and inflammatory processes. Beyond its local effects at the site of inflammation, IL-1 acts as a systemic regulator of hematopoiesis by reprogramming hematopoietic stem and progenitor cells (HSPCs), thereby shaping … Read more

Semin Immunol. 2026 Jun 6;83:102038. doi: 10.1016/j.smim.2026.102038. Online ahead of print. ABSTRACT Stress, a prevalent factor in modern life, profoundly impacts human health by disrupting immune function and intestinal homeostasis. This review elucidates the mechanisms through which stress dysregulates the hypothalamic-pituitary-adrenal (HPA) and sympathetic-adrenal medulla (SAM) axes, leading to altered glucocorticoid and catecholamine levels that … Read more

Semin Immunol. 2026 Jun 5;83:102037. doi: 10.1016/j.smim.2026.102037. Online ahead of print. ABSTRACT Dendritic cells (DCs), the most proficient antigen-presenting cells, bridge innate and adaptive immunity and are critical for anti-cancer immune surveillance. Their function is precisely regulated by protein tyrosine kinases (PTKs), which integrate signals from external stimuli and internal cellular stress to control DC … Read more

Semin Immunol. 2026 May 29;82:102035. doi: 10.1016/j.smim.2026.102035. Online ahead of print. ABSTRACT Latin America and the Caribbean host one of the world’s most complex intersections of ancestry, pathogen exposure, and environmental change, generating an immunological landscape that cannot be fully understood through frameworks derived from high-income regions. The region’s immune profiles reflect the legacy of … Read more

Semin Immunol. 2026 May 25:102036. doi: 10.1016/j.smim.2026.102036. Online ahead of print. NO ABSTRACT PMID:42185114 | DOI:10.1016/j.smim.2026.102036

Semin Immunol. 2026 May 22;82:102034. doi: 10.1016/j.smim.2026.102034. Online ahead of print. ABSTRACT Lymphocytes B cells (B cells) play a determinant role in the pathogenesis of type 1 diabetes (T1D); indeed, B cells antigen-presentation capabilities are largely described as a main contributing pathogenic factor. Recent evidences highlighted the role of islet antigen-reactive B cells as a … Read more

Semin Immunol. 2026 May 19;82:102032. doi: 10.1016/j.smim.2026.102032. Online ahead of print. ABSTRACT Oncolytic virotherapy emerged as a revolutionary approach to immunotherapy in cancer treatment. Newcastle disease virus (NDV), a promising oncolytic agent of the Paramyxoviridae family, has gained considerable attention as an immunotherapeutic agent against cancer mainly due to its inherent tumor selectivity, broad tropism, … Read more