Seminars in Immunology

Semin Immunol. 2026 Jun 6;83:102038. doi: 10.1016/j.smim.2026.102038. Online ahead of print. ABSTRACT Stress, a prevalent factor in modern life, profoundly impacts human health by disrupting immune function and intestinal homeostasis. This review elucidates the mechanisms through which stress dysregulates the hypothalamic-pituitary-adrenal (HPA) and sympathetic-adrenal medulla (SAM) axes, leading to altered glucocorticoid and catecholamine levels that … Read more

Semin Immunol. 2026 Jun 5;83:102037. doi: 10.1016/j.smim.2026.102037. Online ahead of print. ABSTRACT Dendritic cells (DCs), the most proficient antigen-presenting cells, bridge innate and adaptive immunity and are critical for anti-cancer immune surveillance. Their function is precisely regulated by protein tyrosine kinases (PTKs), which integrate signals from external stimuli and internal cellular stress to control DC … Read more

Semin Immunol. 2026 May 29;82:102035. doi: 10.1016/j.smim.2026.102035. Online ahead of print. ABSTRACT Latin America and the Caribbean host one of the world’s most complex intersections of ancestry, pathogen exposure, and environmental change, generating an immunological landscape that cannot be fully understood through frameworks derived from high-income regions. The region’s immune profiles reflect the legacy of … Read more

Semin Immunol. 2026 May 25:102036. doi: 10.1016/j.smim.2026.102036. Online ahead of print. NO ABSTRACT PMID:42185114 | DOI:10.1016/j.smim.2026.102036

Semin Immunol. 2026 May 22;82:102034. doi: 10.1016/j.smim.2026.102034. Online ahead of print. ABSTRACT Lymphocytes B cells (B cells) play a determinant role in the pathogenesis of type 1 diabetes (T1D); indeed, B cells antigen-presentation capabilities are largely described as a main contributing pathogenic factor. Recent evidences highlighted the role of islet antigen-reactive B cells as a … Read more

Semin Immunol. 2026 May 19;82:102032. doi: 10.1016/j.smim.2026.102032. Online ahead of print. ABSTRACT Oncolytic virotherapy emerged as a revolutionary approach to immunotherapy in cancer treatment. Newcastle disease virus (NDV), a promising oncolytic agent of the Paramyxoviridae family, has gained considerable attention as an immunotherapeutic agent against cancer mainly due to its inherent tumor selectivity, broad tropism, … Read more

Semin Immunol. 2026 May 18;82:102033. doi: 10.1016/j.smim.2026.102033. Online ahead of print. ABSTRACT Antigen-presenting cells shape the efficacy of cancer immunotherapies by providing essential signals required for antitumor T-cell response. Dendritic cells (DCs) are central to oncolytic virus (OV)-induced antitumor immunity because they couple tumor-antigen acquisition to cross-presentation and T-cell priming in tumor-draining lymph nodes. In … Read more

Semin Immunol. 2026 May 15;82:102030. doi: 10.1016/j.smim.2026.102030. Online ahead of print. ABSTRACT Chagas disease, caused by Trypanosoma cruzi, remains one of the most striking examples of how parasite genetic diversity and host immune heterogeneity converge to shape chronic infection outcomes. This review integrates findings from studies across Latin America -Mexico and Central America, the Andean … Read more

Semin Immunol. 2026 May 15;82:102031. doi: 10.1016/j.smim.2026.102031. Online ahead of print. ABSTRACT The interleukin-1 (IL-1) superfamily encompasses a group of cytokines with central roles in inflammation and immune regulation. IL-1 is directly implicated in activating survival and proliferative pathways in transformed cells, orchestrating the angiogenic switch, remodeling the extracellular matrix, and driving invasion and metastatic … Read more

Semin Immunol. 2026 May 5;82:102029. doi: 10.1016/j.smim.2026.102029. Online ahead of print. ABSTRACT Chimeric antigen receptor (CAR) T cell therapy has transformed the treatment of hematological malignancies, offering durable responses in conditions such as diffuse large cell lymphoma, B-cell leukemias and multiple myeloma. However, access to this therapy is still limited in low- and middle-income nations, … Read more