Trends Immunol. 2025 Oct 21:S1471-4906(25)00246-7. doi: 10.1016/j.it.2025.10.002. Online ahead of print.
ABSTRACT
Sepsis, a life-threatening condition triggered by infection, disrupts the body’s immune balance and remains a major global health challenge. This forum explores the dual roles of cytokines in sepsis: their overactivation drives ‘cytokine storms,’ and dysregulation leads to immunosuppression. It also discusses regulatory mechanisms for developing targeted therapies.
PMID:41125507 | DOI:10.1016/j.it.2025.10.002