Trends Immunol. 2025 Nov 19:S1471-4906(25)00286-8. doi: 10.1016/j.it.2025.11.003. Online ahead of print.

ABSTRACT

Chi and colleagues revealed that dietary cysteine enhances intestinal stem cell (ISC) regeneration, driving coenzyme A (CoA) synthesis and expansion of intraepithelial (IEL) CD8αβ⁺ T cells that secrete IL-22. This epithelial-immune crosstalk potentiates ISC repair after injury, highlighting a metabolism-immune axis linking cysteine sensing to tissue regeneration.

PMID:41260991 | DOI:10.1016/j.it.2025.11.003