Mucosal Immunol. 2026 Jan 20:S1933-0219(26)00006-1. doi: 10.1016/j.mucimm.2026.01.006. Online ahead of print.

ABSTRACT

Two studies in Nature Immunology by Jakob, Sterczyk et al. and Pirzgalska et al. show that neuron-derived vasoactive intestinal peptide (VIP) regulates intestinal epithelial differentiation and orchestrates immune responses. Through its receptor VIPR1, VIP restrains secretory lineage expansion, balances type 1 and type 2 immunity, and establishes a neuro-epithelial circuit preserving gut barrier integrity.

PMID:41571149 | DOI:10.1016/j.mucimm.2026.01.006