Mucosal Immunology

Mucosal Immunol. 2026 Sep 10:100403. doi: 10.1016/j.mucimm.2026.100403. Online ahead of print. ABSTRACT Mucosal-associated invariant T (MAIT) cells are an unconventional subset of T cells that respond to vitamin B2 metabolites from a range of bacteria and fungi. We have previously reported that peripheral MAIT cells are activated during acute HIV infection (AHI) in a manner … Read more

Mucosal Immunol. 2026 Sep 7:100402. doi: 10.1016/j.mucimm.2026.100402. Online ahead of print. ABSTRACT Intestinal dendritic cells (DC) orchestrate the adaptive immune response that balances protection against pathogens and tolerance towards harmless antigens. Yet, it remains largely unknown what molecular mechanisms underly this functional duality. Heligmosomoides polygyrus bakeri (Hpb) is a naturally occurring parasite in mice characterised … Read more

Mucosal Immunol. 2026 Aug 24:100401. doi: 10.1016/j.mucimm.2026.100401. Online ahead of print. ABSTRACT Infants require repeated immunizations of injectable-type vaccines against different pathogens because their immune systems are weaker than those of adults. However, these injectable vaccines cause physical and psychological discomfort. Therefore, there is an urgent need to develop pain-free mucosal vaccines that are optimized … Read more

Mucosal Immunol. 2026 Aug 13:100400. doi: 10.1016/j.mucimm.2026.100400. Online ahead of print. ABSTRACT Immune dysregulation is increasingly recognized as a key contributor to male infertility, yet the role of the efferent ductules in reproductive immune homeostasis remains unexplored. Located between the immune-privileged testis and the epididymis, efferent ductules are essential for male fertility by reabsorbing over … Read more

Mucosal Immunol. 2026 Aug 10:100399. doi: 10.1016/j.mucimm.2026.100399. Online ahead of print. ABSTRACT Early life is characterized by heightened susceptibility to respiratory pathogens, yet the immune mechanisms that predispose infants to infection remain poorly defined. Using an infant mouse model of Streptococcus pneumoniae (Spn) colonization, we identify an age-dependent delay in IL-17 A production that was … Read more

Mucosal Immunol. 2026 Aug 10:100398. doi: 10.1016/j.mucimm.2026.100398. Online ahead of print. ABSTRACT EoE is an inflammatory condition characterised by tissue lesions and significant activation of immune cells in the oesophageal mucosa. Phenotypic and functional analyses in this study revealed widespread accumulation and activation of multiple immune cell types, with eosinophils showing the most notable expansion … Read more

Mucosal Immunol. 2026 Aug 1:100392. doi: 10.1016/j.mucimm.2026.100392. Online ahead of print. ABSTRACT SARS-CoV-2 primarily targets epithelial cells in the respiratory and intestinal tracts where its cognate receptor ACE2 and obligate processing enzymes furin and TMPRSS2 are richly expressed. However, compared with severe inflammation and tissue damage in the lungs of a COVID-19 patient, clinical lesions … Read more

Mucosal Immunol. 2026 Jul 29:100384. doi: 10.1016/j.mucimm.2026.100384. Online ahead of print. ABSTRACT Patients with allergic asthma exhibit distinct temporal variations in symptoms and disease severity, which oscillate across the 24 h day. We have previously shown that the molecular circadian clock plays a critical role in temporally gating the response to allergen challenge in mice. … Read more

Mucosal Immunol. 2026 Jul 26:100391. doi: 10.1016/j.mucimm.2026.100391. Online ahead of print. ABSTRACT Bacille Calmette-Guérin (BCG) is the only licensed vaccine against tuberculosis (TB) but provides inconsistent protection against disease. Alveolar macrophages (AM) are widely considered the primary myeloid mediators of BCG-induced lung immunity, whereas the contribution of lung interstitial macrophages (IM) remains poorly defined. Here, … Read more

Mucosal Immunol. 2026 Jul 25:100390. doi: 10.1016/j.mucimm.2026.100390. Online ahead of print. ABSTRACT B cells play a crucial role in maintaining immune homeostasis at mucosal surfaces, including those of the gastrointestinal (GI) tract. Perturbed humoral immunity and antibody-mediated functions of B cells are well described in patients with chronic GI inflammatory diseases. However, our understanding of … Read more