Trends Immunol. 2026 Mar 18:S1471-4906(26)00015-3. doi: 10.1016/j.it.2026.01.012. Online ahead of print.
ABSTRACT
Deciphering how mRNA vaccines generate humoral immunity could accelerate next-generation vaccine design. Castaño et al. reveal that mRNA-lipid nanoparticle vaccines employ a dual-adjuvant mechanism: nucleoside-modified mRNA triggers type I interferons to mature dendritic cells, while lipid nanoparticles induce a pro-T follicular helper cell program, together promoting robust germinal center responses.
PMID:41856882 | DOI:10.1016/j.it.2026.01.012