Trends Immunol. 2026 Mar 25:S1471-4906(26)00061-X. doi: 10.1016/j.it.2026.03.002. Online ahead of print.
ABSTRACT
Group 3 innate lymphoid cells (ILC3s) promote gastrointestinal health, dynamically interface with diet and microbes, and become impaired during chronic inflammation or metabolic syndrome. Torrico and colleagues uncover a key pathway rapidly disrupting ILC3 homeostasis in the intestines of humans and mice following the consumption of a high-fat diet.
PMID:41887976 | DOI:10.1016/j.it.2026.03.002