CA72-4 derived from synovial cells inhibits monosodium urate-induced macrophage M1 polarization by activating the TIGIT/SHP-1 axis through binding to Siglec-15. Honglei Hu Xuefeng Bai Lingyue Zhang Hongmei Zhang Qiang You Shujuan Wang Xueshan Bai a Department of Endocrinology, Zibo Central Hospital, Zibo, Shandong Province, P.R. Chinab Zibo Municipal Hospital, Zibo, Shandong Province, P.R. Chinac School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University, Jinan, Shandong Province, P.R. China