Integrated bioinformatics reveals tubulointerstitial immune microenvironment signatures and machine learning-driven prognostication of clinical treatment response in lupus nephritis. Jialong Ke Guanghong Gu Wenpeng Ni Jialin He Zhouyu Zeng Runpei Lin Jianming Peng Kunyi Deng Lijuan Wen Yanhui Chen Nan Tan Chilun Zhang a Clinical Laboratory, Boai Hospital of Zhongshan, Zhongshan, Guangdong, Chinab Clinical Laboratory, Zhongshan Torch Development Zone People’s Hospital, Zhongshan, Guangdong, Chinac Research and Teaching Department, Boai Hospital of Zhongshan, Zhongshan, Guangdong, China

Volume 59, Issue 1, December 2026.

Long non-coding RNA H19 contributes to M1 macrophage polarization mediated inflammation via miR-145-5p-PAI-1 axis in systemic lupus erythematosus. Cheng-lei Zhao Yong Zhang Jun-kai Guo Juan Wang Chun-you Wang Zhi-qiang Song Yi You a Department of Dermatology, The First Affiliated Hospital (Southwest Hospital) of Army Medical University, Chongqing, Chinab Chongqing Municipal Health Commission Key Laboratory of Immunological Skin Diseases, Chongqing, Chinac Department of Cell Biology, National Translational Science Center for Molecular Medicine, Fourth Military Medical University, and State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases, Xi’an, Chinad Department of Pulmonary and Critical Care of Medicine, The First Affiliated Hospital of Fourth Military Medical University, Xi’an, Shaanxi Province, China

Volume 59, Issue 1, December 2026.

CA72-4 derived from synovial cells inhibits monosodium urate-induced macrophage M1 polarization by activating the TIGIT/SHP-1 axis through binding to Siglec-15. Honglei Hu Xuefeng Bai Lingyue Zhang Hongmei Zhang Qiang You Shujuan Wang Xueshan Bai a Department of Endocrinology, Zibo Central Hospital, Zibo, Shandong Province, P.R. Chinab Zibo Municipal Hospital, Zibo, Shandong Province, P.R. Chinac School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University, Jinan, Shandong Province, P.R. China

Volume 59, Issue 1, December 2026.

Molecular mechanism of Mir-27B-3P carried by bronchial epithelial cell-derived extracellular vesicle in airway inflammation in asthmatic mice. Niu Ding Siran Xu Yanping Chen Jin Zhang Chang Xu Tao Chen Yanni Meng a International Medical Special Ward, Hunan Children’s Hospital, Changsha, People’s Republic of Chinab Department of Respiratory Medicine, Hunan Children’s Hospital, Changsha, People’s Republic of Chinac Department of Pulmonary and Critical Care Medicine, Zigong First People’s Hospital, Zigong, People’s Republic of China

Volume 59, Issue 1, December 2026.

Identification of the immune-related diagnostic biomarkers between Graves’ disease and thyroid carcinoma based on comprehensive bioinformatics analysis and machine learning. Yanting Zhu Xiaoyu Qu Jingying Pan Hong Zeng Zichuan Yu Xitong Geng Hao Zheng Shuhan Huang Da Huang Rong Xie a Department of Thyroid Surgery, Second Affiliated Hospital of Nanchang University, Nanchang, People’s Republic of Chinab HuanKui Academy, Nanchang University, Nanchang, People’s Republic of Chinac School of Ophthalmology & Optometry, Nanchang University, Nanchang, People’s Republic of Chinad The First Clinical Medical College, Nanchang University, Nanchang, People’s Republic of Chinae The Second Clinical Medical College, Nanchang University, Nanchang, People’s Republic of China

Volume 59, Issue 1, December 2026.

The shared mechanisms and potential diagnostic markers for IgA nephropathy and celiac disease. Shaoguo Tao Xuemei Fan Xiaoyou Liu Yannic Becker Patricia Schroder Qian Zhao Zhuoying He Hanzhi Jiang Jie Xiao Hermann Haller Guibao Ke a Department of Nephrology, The First affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, People’s Republic of Chinab The People’s Hospital of Suiyang, Zunyi, People’s Republic of Chinac Organ Transplant Center, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, People’s Republic of Chinad Mount Desert Island Biological Laboratory, Bar Harbor, Maine, USAe Department of Nephrology and Hypertension, Hannover Medical School, Hannover, Germany

Volume 59, Issue 1, December 2026.

Exosomal circ_001895 from lung cancer cells drives M2 macrophage polarization via the miR-20a-5p/JAK1/STAT3 axis to promote tumor progression. Zunqiao Wang Bin Wang Yun Gao Jinyuan Liu Keping Wang a Department of Thoracic Surgery, Nanjing Medical University Affiliated Brain Hospital, Nanjing, Jiangsu, Chinab Department of Pharmacy, Nanjing Medical University Affiliated Brain Hospital, Nanjing, Jiangsu, Chinac Department of Thoracic Surgery, Nanjing Medical University, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, Jiangsu, China

Volume 59, Issue 1, December 2026.

Transcriptomic subtyping of COVID-19 reveals three distinct immune response profile. Feifei Qiao Yuhui Zhao Kaixin Yao Shan Song Leilei Zheng Qian Wang Jingxi Hu Yongqiang Lv Feng Han Feng Li a Department of Head and Neck Surgery, Shanxi Province Cancer Hospital, Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences, Taiyuan, Shanxi, Chinab Department of Rheumatology, Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, Chinac Department of Nephrology, Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, Chinad Department of Rheumatology and Clinical Immunology, Peking University First Hospital, West District, Beijing, Chinae Department of Otolaryngology-Head and Neck Surgery, the Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, Chinaf Department of Nephrology, The Fifth Clinical Medical College of Shanxi Medical University, Taiyuan, Shanxi, Chinag Department of Urology, The First Hospital of Shanxi Medical University, Taiyuan, Shanxi, Chinah Department of Scientific Research, Shanxi Province Cancer Hospital, Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences, Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan, Shanxi, Chinai Department of Information Management, Shanxi Province Cancer Hospital, Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences, Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan, Shanxi, Chinaj Department of Clinical Laboratory, Shanxi Province Cancer Hospital, Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences, Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan, Shanxi, China

Volume 59, Issue 1, December 2026.

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