Curr Opin Immunol. 2026 Sep 17;103:102842. doi: 10.1016/j.coi.2026.102842. Online ahead of print.
ABSTRACT
Antiphospholipid syndrome (APS) is characterised by thrombosis and/or pregnancy morbidity associated with persistent antiphospholipid antibodies (aPL). Beyond the criteria antibodies, non-criteria aPL, particularly antiphosphatidylserine/prothrombin (aPS/PT), have emerged as clinically relevant aPL in the diagnosis of APS. aPS/PT antibodies, especially IgG, are strongly associated with thrombosis, obstetric morbidity, and LA positivity. Most importantly, aPS/PT identify high-risk aPL profiles and are detectable in seronegative APS. aPS/PT antibodies are among the most informative non-criteria aPL and add diagnostic and prognostic value in APS.
PMID:42753374 | DOI:10.1016/j.coi.2026.102842