Cao, J., Chen, K., Hu, K., Mi, X., Pan, Y., Xiao, D., Liu, S., Xiao, L., Zhou, L., Tao, Y., Tang, J.

USP2-mediated PPAR{gamma} stabilization promotes hepatocellular carcinoma progression and M2 macrophage polarization via oleic acid

5 de November de 2025 by Cao, J., Chen, K., Hu, K., Mi, X., Pan, Y., Xiao, D., Liu, S., Xiao, L., Zhou, L., Tao, Y., Tang, J.

Background
Hepatocellular carcinoma (HCC) is an aggressive liver cancer with poor prognosis. Deubiquitinating enzymes (DUBs) are critical regulators of tumor progression, yet the functional significance of DUBs in HCC remains poorly understood.

Metho…