Chen, S., Chen, Z., Zhou, B., Chen, Y., Huang, Y., Cao, J., Shen, L., Zheng, Y.

PRMT5 deficiency in myeloid cells reprograms macrophages to enhance antitumor immunity and synergizes with anti-PD-L1 therapy

5 de April de 2025 by Chen, S., Chen, Z., Zhou, B., Chen, Y., Huang, Y., Cao, J., Shen, L., Zheng, Y.

Background
Arginine methyltransferase protein arginine methyltransferase 5 (PRMT5) plays a significant role in immune regulation, particularly within the tumor microenvironment (TME). Macrophages are crucial modulators of both innate and adaptive immu…