Chen, T., Liu, J., Wang, C., Wang, Z., Zhou, J., Lin, J., Mao, J., Pan, T., Wang, J., Xu, H., He, X., Wu, D., Liu, Z.

ALOX5 contributes to glioma progression by promoting 5-HETE-mediated immunosuppressive M2 polarization and PD-L1 expression of glioma-associated microglia/macrophages

14 de August de 2024 by Chen, T., Liu, J., Wang, C., Wang, Z., Zhou, J., Lin, J., Mao, J., Pan, T., Wang, J., Xu, H., He, X., Wu, D., Liu, Z.

Background
Oxylipin metabolism plays an essential role in glioma progression and immune modulation in the tumor microenvironment. Lipid metabolic reprogramming has been linked to macrophage remodeling, while the understanding of oxylipins and their ca…