Chen, Y., Jia, H., Zhang, X., Zhao, H., Xiao, Y., Li, N., Yao, Y., Xing, X.

Disruption of GPSM1/CSF1 signaling reprograms tumor-associated macrophages to overcome anti-PD-1 resistance in colorectal cancer

26 de February de 2025 by Chen, Y., Jia, H., Zhang, X., Zhao, H., Xiao, Y., Li, N., Yao, Y., Xing, X.

Background
Immune checkpoint blockade (ICB) therapies, particularly anti-PD-1, benefit only a limited subset of colorectal cancer (CRC) patients. G-protein signaling modulator 1 (GPSM1) is implicated in immunity and oncology, yet its role in regulatin…