Cheng, J., Lu, J., Gao, Z., Xiao, Y., Chen, P., Zhou, M., Huang, D., Zhao, Z., Zhang, X., Zhao, Y., Li, M., Gu, J.

CLEC2B-KLRB1 axis acts as an immune checkpoint, governing the exhaustion of CD8+ T cells and their resistance to immune checkpoint blockade

28 de May de 2026 by Cheng, J., Lu, J., Gao, Z., Xiao, Y., Chen, P., Zhou, M., Huang, D., Zhao, Z., Zhang, X., Zhao, Y., Li, M., Gu, J.

Background
Many patients with cancer benefit little from immune checkpoint blockade (ICB), a major obstacle to immunotherapy for decades. Finding alternative immune checkpoints that control CD8+ T-cell exhaustion is urgent if we are to improve the eff…