Du, Q., Han, Z., Zhang, Y., Li, Y., Sun, A., Wang, B., Chen, Y., Wang, X.

Gasdermin D antagonizes immunosuppression in prostate cancer by inducing LAMC2 degradation to block M2 macrophage polarization

27 de May de 2026 by Du, Q., Han, Z., Zhang, Y., Li, Y., Sun, A., Wang, B., Chen, Y., Wang, X.

Background
The N-terminal domain of gasdermin D (GSDMD) is a known suppressor of prostate cancer (PCa), primarily recognized for its tumoricidal pyroptotic function. However, research on the full-length GSDMD protein and its relationship with PCa rema…