Hou, L., Jiao, D., Dai, H., Zhang, J., Wang, L., Gong, X., Qi, C., Guo, X., Liu, Z.

C-type lectin domain family 5 member A-mediated activation of macrophages via a bispecific antibody enhances anti-HER2 therapy

29 de April de 2026 by Hou, L., Jiao, D., Dai, H., Zhang, J., Wang, L., Gong, X., Qi, C., Guo, X., Liu, Z.

Background
Although HER2-targeted therapies have dramatically improved outcomes for patients with HER2-positive breast cancer, the immunosuppressive tumor microenvironment remains a major barrier to effective immunotherapy in this subtype. Therefore, …