Hu, W., Tao, Z., Guo, W., Ding, W., Huang, S., Li, J., Peng, H., Zeng, L., Chen, Z., Qiu, R., Kang, Z., Yao, Y., Chen, X.

Protein catenation potentiates antitumor activity of malaria VAR2CSA navigation CAR-T cells in a mouse model of hematological malignancies

19 de November de 2025 by Hu, W., Tao, Z., Guo, W., Ding, W., Huang, S., Li, J., Peng, H., Zeng, L., Chen, Z., Qiu, R., Kang, Z., Yao, Y., Chen, X.

Background
While CD19-targeting chimeric antigen receptor T-cell (CAR-T) therapies have shown efficacy in B-cell hematological malignancies, treatment of antigen-negative or relapsed tumors remains challenging. The recombinant malaria protein VAR2CSA …