inmunoadmin

Toolkit for mapping the clonal landscape of tumor-infiltrating B cells. E O Serebrovskaya

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Semin Immunol. 2024 Mar;72:101864. doi: 10.1016/j.smim.2024.101864. Epub 2024 Jan 31. ABSTRACT Our current understanding of whether B cell involvement in the tumor microenvironment benefits the patient or the tumor – in distinct cancers, subcohorts and individual patients – is quite limited. Both statements are probably true in most cases: certain clonal B cell populations contribute … Read more

Durability of immune responses to SARS-CoV-2 infection and vaccination. Mehul S Suthar

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Semin Immunol. 2024 Jun 10;73:101884. doi: 10.1016/j.smim.2024.101884. Online ahead of print. ABSTRACT Infection with SARS-CoV-2 in humans has caused a pandemic of unprecedented dimensions. SARS-CoV-2 is primarily transmitted through respiratory droplets and targets ciliated epithelial cells in the nasal cavity, trachea, and lungs by utilizing the cellular receptor angiotensin-converting enzyme 2 (ACE2). The innate immune … Read more

Early life microbiome influences on development of the mucosal innate immune system. Aline Ignacio

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Semin Immunol. 2024 May 23;73:101885. doi: 10.1016/j.smim.2024.101885. Online ahead of print. ABSTRACT The gut microbiota is well known to possess immunomodulatory capacities, influencing a multitude of cellular signalling pathways to maintain host homeostasis. Although the formation of the immune system initiates before birth in a sterile environment, an emerging body of literature indicates that the … Read more

B cell clonality in cancer. E A Bryushkova

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Semin Immunol. 2024 Mar;72:101874. doi: 10.1016/j.smim.2024.101874. Epub 2024 Mar 19. ABSTRACT Carcinogenesis in the process of long-term co-evolution of tumor cells and immune environment essentially becomes possible due to incorrect decisions made, remembered, and reproduced by the immune system at the level of clonal populations of antigen-specific T- and B-lymphocytes. Tumor-immunity interaction determines the nature … Read more

Systems biology of B cells in COVID-19. Matthew C Woodruff

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Semin Immunol. 2024 Mar;72:101875. doi: 10.1016/j.smim.2024.101875. Epub 2024 Mar 14. ABSTRACT The integration of multi-‘omic datasets into complex systems-wide assessments has become a mainstay in immunologic investigation. This focus on high-dimensional data collection and analysis was on full display in the investigation of COVID-19, the respiratory illness resulting from infection by the novel coronavirus SARS-CoV-2. … Read more

Systems analysis of innate and adaptive immunity in Long COVID. Michael J Peluso

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Semin Immunol. 2024 Mar;72:101873. doi: 10.1016/j.smim.2024.101873. Epub 2024 Mar 8. ABSTRACT Since the onset of the COVID-19 pandemic, significant progress has been made in developing effective preventive and therapeutic strategies against severe acute SARS-CoV-2 infection. However, the management of Long COVID (LC), an infection-associated chronic condition that has been estimated to affect 5-20% of individuals … Read more

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