inmunoadmin 
La incorporación de la inmunogenética en los programas de detección del cáncer de pulmón puede constituir una herramienta básica a tener en cuenta junto con otros factores como los ambientales y la herencia genética. El riesgo de cáncer está influenciado por mutaciones hereditarias, errores de replicación del ADN y factores ambientales. Sin embargo, no hay … Read more
Antibodies can initiate immune receptor signaling. Lippert et al. provide mechanistic insight into this effect, showing that antibody agonists trigger receptor signaling by locally excluding receptor-type protein tyrosine phosphatases from sites of ant…
Interaction of CD27 on naive T cells with CD70 on antigen-presenting cells is necessary for T cell memory fate determination. Jaeger-Ruckstuhl et al. engineer a trimeric CD70-ligand and assess consequences of CD27 ligation on receptor regulation, early…
The fate of disease-associated microglia (DAM) in neuropathologies remains elusive. Lan et al. generated an Spp1 fate-mapping model to track DAM-like microglia and find that the plasticity of DAM is age dependent. Juvenile stroke leads to the eliminati…
Non-alcoholic fatty liver disease and its progressive form, non-alcoholic steatohepatitis (NASH), are a prevalent cause of chronic liver disease. Savage et al. demonstrate that regulatory T (Treg) cells are enriched in mouse and human NASH and find tha…
Massoni-Badosa et al. present a comprehensive human tonsil cell atlas, identifying 121 cell types and states through multimodal single-cell profiling. This atlas elucidates cell differentiation pathways and regulatory circuits, defines cell states, and…
Mutations of the CBP/p300 histone acetyltransferase (HAT) domain can be linked to leukemic transition in humans. Jaschke et al. reveal that a small-molecule inhibitor of the CBP/p300 histone acetyltransferase activity acutely mobilizes leukocytes from …
When and how T cells make effector or memory decisions is not fully resolved. Abadie, Clark, and Valanparambil et al. uncover a reversible epigenetic switch enabling memory cells to diverge early after activation or dedifferentiate from effector cells …
Although it is known that pro- and anti-inflammatory neutrophils exist, the mechanisms that dictate their polarization remain unclear. Gour et al. report that neutrophils express a canonical neuronal receptor, Mrgpra1, and a neuropeptide ligand, neurop…
Tuft cells are central regulators of type 2 immunity in the intestine. Eshleman et al. reveal that commensal bacterial-derived butyrate restricts stem cell development into tuft cells through the epigenetic-modifying enzyme HDAC3. The microbiota can th…
