Specialized T cells can support tissue remodeling, but how T cells contribute to mammary gland remodeling during pregnancy is not fully understood. In a recent Cell issue, Corral et al. demonstrate that self-sensing T cells migrate to the mammary gland…
cGAS-cGAMP-STING and OAS-2-5A-RNase L are evolutionarily convergent innate immune pathways. cGAMP acts as an immunotransmitter; what about 2-5A? In this issue of Immunity, Huai et al. map the transfer of 2-5A between cells, establishing it as a bona fi…
Mitochondrial dysfunction is a feature of cellular senescence. Lai et al. find that senescent tumor cells release mitochondrial (mt)DNA into the extracellular space, where it is taken up by PMN-MDSCs. Internalized mtDNA activates the cGAS-STING-NF-κB p…
While neuroinflammatory responses driven by microglia and astrocytes have been extensively linked to neurodegenerative disease progression in amyotrophic lateral sclerosis (ALS), the specific pathways that coordinate glial cell-dependent neuroinflammat…
The combination of antiangiogenic and immune checkpoint inhibitor (ICI) treatment is active in solid tumors, but the mechanism of response remains unclear. In this issue of Immunity, Benmebarek et al. show that anti-vascular endothelial growth factor e…
Long-lived memory B cells developing from germinal centers (GCs) are important contributors to protective immunity. In this issue of Immunity, Luo et al. report that during primary responses, T cell-derived interleukin-9 potentiates differentiation of …
Just a few weeks ago, researchers and educators connected to immunology lost a wonderful friend and colleague: Michael Cancro, professor of pathology and lab medicine at the University of Pennsylvania, passed away suddenly at his home just outside Phil…
CTLA-4 exists as membrane (mCTLA-4) and soluble (sCTLA-4) forms. Immunological roles of sCTLA-4 are scarcely known. With mice deficient in either sCTLA-4 or mCTLA-4, Osaki et al. show that sCTLA-4, which is predominantly produced by Treg cells, suppres…
B cells that give rise to neutralizing antibody responses can be extremely rare in the naive B cell repertoire. Madden et al. show that delivery strategy and adjuvant selection affect the recruitment and expansion of rare broadly neutralizing antibody-…
In this perspective, Andersen and colleagues examine how host immunity shapes the emergence, evolution, and persistence of novel and emerging viruses. They highlight the role of antibody-driven selection in viral adaptation and endemicity, emphasizing …
