Antigenic and environmental stimuli sensed by innate and adaptive immune cells trigger cognate functions that allow the coordination of the appropriate immune response. In this issue of Immunity, Tzerpos et al. and Jay et al. demonstrate that chromatin…
Accumulating evidence implicates sensory neurons in tumor progression, but signals linking nociceptive activity to impaired antitumor immunity remain unclear. In a recent issue of Cell, Ho et al. show that nociceptor activation impedes TLS assembly thr…
Candida albicans induces Th17 cells, but their origins remain unresolved. In this issue of Immunity, Martini et al. show that the mouth is a reservoir for fungal Th17 cells that adopt pathogenic signatures in the gut during Crohn’s disease.
The unprecedented recent advancement in the field of interoception (sensing self) has introduced neuromodulation as a realistic treatment approach. Shibuya et al. identified an ear-to-lung reflex in which activation of auricular-innervating TRPV1+ vaga…
Sepsis lacks effective therapeutic interventions. Fish et al. examine sepsis patients and identify three temporal immune states with distinct resistance, disease tolerance, and resilience program trajectories. Early and late immune responses do not ali…
Cytokine cues reshape how chromatin folds to control immune gene activity. Jay et al. show that cytokine signals reposition the Ets1 super-enhancer toward the geometric center of the locus and sustain Ets1 expression required for helper T cell differen…
The role of noncoding lncRNAs in human disease is difficult to ascertain. Yang-Fischer et al. identify lnc15 (2310015A10Rik/ENSMUSG00000097729) as a cytoplasmic brake on intestinal inflammation. lnc15 expression is decreased in active human inflammator…
Ginhoux and colleagues review the mechanisms underlying the impact of obesity on cancer susceptibility, progression, and response to therapy. They discuss how metabolic stress reprograms myeloid cells, particularly macrophages, driving chronic inflamma…
The intestinal barrier harbors numerous intraepithelial lymphocytes (IELs) that promote tissue integrity and whose dysfunction contributes to disease. Earley et al. studied the G-protein coupled receptor signals regulating IEL movement and function and…
Recent studies have expanded the field of autophagy in immunity to include related but incompletely understood noncanonical autophagy processes. Deretic reviews these advancements in the context of immunity, offering a unifying framework for canonical …
