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Integrins α5β1 and αvβ3 Differentially Participate in the Recruitment and Reprogramming of Tumor-associated Macrophages in the In Vitro and In Vivo Models of Breast Tumor

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J Immunol. 2024 Sep 27:ji2400180. doi: 10.4049/jimmunol.2400180. Online ahead of print. ABSTRACT Tumor-associated macrophages (TAMs) drive the protumorigenic responses and facilitate tumor progression via matrix remodeling, angiogenesis, and immunosuppression by interacting with extracellular matrix proteins via integrins. However, the expression dynamics of integrin and its correlation with TAM functional programming in the tumors remain unexplored. … Read more

MARCH8 Mediates K27-Linked Polyubiquitination of IL-7 Receptor α to Negatively Regulate IL-7-Triggered T Cell Homeostasis

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J Immunol. 2024 Sep 23:ji2400253. doi: 10.4049/jimmunol.2400253. Online ahead of print. ABSTRACT IL-7 is a cytokine produced by stromal cells, which binds to IL-7Rα and plays an important role for homeostasis of T lymphocytes. Excessive activities of IL-7-triggered signaling pathways causes autoimmune diseases. How IL-7-triggered signaling and immune effects are regulated is not fully understood. … Read more

Type I IFN Induces TCR-dependent and -independent Antimicrobial Responses in γδ Intraepithelial Lymphocytes

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J Immunol. 2024 Sep 23:ji2400138. doi: 10.4049/jimmunol.2400138. Online ahead of print. ABSTRACT Intraepithelial lymphocytes (IELs) expressing the TCRγδ survey the intestinal epithelium to limit the invasion of microbial pathogens. The production of type I IFN is a central component of an antiviral immune response, yet how these proinflammatory cytokines contribute to γδ IEL effector function … Read more

Circulating Immune Cells from Early- and Late-onset Pre-eclampsia Displays Distinct Profiles with Differential Impact on Endothelial Activation

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J Immunol. 2024 Sep 20:ji2400196. doi: 10.4049/jimmunol.2400196. Online ahead of print. ABSTRACT Pre-eclampsia (PE) affects 5-8% of pregnancies and has detrimental effects on maternal-fetal health. PE is characterized by de novo hypertension after 20 wk of gestation and end-organ damage. Systemic inflammatory imbalance has been associated with PE, but its contribution to the pathology is … Read more

IL-1β Induces Human Endothelial Surface Expression of IL-15 by Relieving let-7c-3p Suppression of Protein Translation

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J Immunol. 2024 Sep 20:ji2400331. doi: 10.4049/jimmunol.2400331. Online ahead of print. ABSTRACT Expression of IL-15 on the surface of human graft endothelial cells (ECs) bound to the IL-15Rα subunit can increase the activation of CTLs, potentiating allograft rejection. Our previous work showed that surface expression of this protein complex could be induced by alloantibody-mediated complement … Read more

Rapamycin Prevents Expansion of Costimulation Blockade-resistant CD8+ Alloreactive Memory Cells following Depletional Induction in Renal Transplant Recipients

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J Immunol. 2024 Sep 20:ji2400146. doi: 10.4049/jimmunol.2400146. Online ahead of print. ABSTRACT Alemtuzumab induction with belatacept/rapamycin-based maintenance immunotherapy (ABR) prevents kidney allograft rejection and specifically limits early costimulation blockade-resistant rejection (CoBRR). To evaluate the mechanisms by which this regimen alters CoBRR, we characterized the phenotype and functional response of preexisting memory cells to allogeneic endothelial … Read more

Chitinase 3-like-1 Inhibits Innate Antitumor and Tissue Remodeling Immune Responses by Regulating CD47-SIRPα- and CD24-Siglec10-Mediated Phagocytosis

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J Immunol. 2024 Sep 18:ji2400035. doi: 10.4049/jimmunol.2400035. Online ahead of print. ABSTRACT Innate immune responses such as phagocytosis are critically linked to the generation of adaptive immune responses against the neoantigens in cancer and the efferocytosis that is essential for homeostasis in diseases characterized by lung injury, inflammation, and remodeling as in chronic obstructive pulmonary … Read more

Linking signal input, cell state, and spatial context to inflammatory responses

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Curr Opin Immunol. 2024 Sep 11;91:102462. doi: 10.1016/j.coi.2024.102462. Online ahead of print. ABSTRACT Signal integration is central to a causal understanding of appropriately scaled inflammatory responses. Here, we discuss recent progress in our understanding of the stimulus-response linkages downstream of pro-inflammatory inputs, with special attention to (1) the impact of cell state on the specificity … Read more

T follicular helper cells in food allergy

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Curr Opin Immunol. 2024 Sep 13;91:102461. doi: 10.1016/j.coi.2024.102461. Online ahead of print. ABSTRACT T follicular helper (Tfh) cells help direct the production of antibodies by B cells. In addition to promoting antibody responses to vaccination and infection, Tfh cells have been found to mediate antibody production to food antigens. Work over the past decade has … Read more

Microbiome modulation of antigen presentation in tolerance and inflammation

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Curr Opin Immunol. 2024 Sep 13;91:102471. doi: 10.1016/j.coi.2024.102471. Online ahead of print. ABSTRACT The microbiome regulates mammalian immune responses from early life to adulthood. Antigen presentation, orchestrating these responses, integrates commensal and pathogenic signals. However, the temporal and spatial specificity of microbiome impacts on antigen presentation and downstream tolerance versus inflammation remain incompletely understood. Herein, … Read more

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