Jarrard, D., Eickhoff, J., Kyriakopoulos, C. E., Jeon, D., Tonelli, T. P., Johnson, L., Huang, W., McNeel, D. G.

Androgen deprivation, androgen receptor-targeted vaccination, and nivolumab in patients with high-risk localized prostate cancer

4 de March de 2026 by Jarrard, D., Eickhoff, J., Kyriakopoulos, C. E., Jeon, D., Tonelli, T. P., Johnson, L., Huang, W., McNeel, D. G.

Background
In murine studies, we demonstrated that a DNA vaccine encoding the androgen receptor (pTVG-AR) given prior to androgen deprivation elicited prostate tumor-infiltrating lymphocytes and an antitumor response. The current trial evaluated this …