Leshem, R., Sefton, K. N., Wong, C. W., Lin, I.-H., Isaac, D. T., Niepel, M., Hurlstone, A.

Combined PARP14 inhibition and PD-1 blockade promotes cytotoxic T cell quiescence and modulates macrophage polarization in relapsed melanoma

27 de January de 2025 by Leshem, R., Sefton, K. N., Wong, C. W., Lin, I.-H., Isaac, D. T., Niepel, M., Hurlstone, A.

Background
Programmed cell death 1 (PD-1) signaling blockade by immune checkpoint inhibitors (ICI) effectively restores immune surveillance to treat melanoma. However, chronic interferon-gamma (IFN)-induced immune homeostatic responses in melanoma cel…