Li, J., Liu, T., Xiao, W., Zhao, D., Li, Q., Liu, S., Li, X., Tong, Y., Li, H., Jiang, H., Wu, S., Li, Z., Tu, H., Gan, Y.

SMAD7 drives natural killer cell antitumor activity through canonical TGF-{beta} blockade and non-canonical transcriptional activation of STAT5A

9 de April de 2026 by Li, J., Liu, T., Xiao, W., Zhao, D., Li, Q., Liu, S., Li, X., Tong, Y., Li, H., Jiang, H., Wu, S., Li, Z., Tu, H., Gan, Y.

Background
Natural killer (NK) cells are key effectors in antitumor immunity, yet their function is markedly suppressed by transforming growth factor-β (TGF-β) in the tumor microenvironment. SMAD7 is an established intracellular antagonist o…