Li, W., Chen, J., Li, J., Wang, S., Chen, Z., Zhao, L., Zhao, Y., Gu, L., Liu, J., Zhang, Y., Yang, X., Chen, T., Guo, Z.

Envirotune-CAR-T: a hypoxia-responsive and glutamine-enhanced CAR-T cell therapy for overcoming tumor microenvironment-mediated suppression

13 de October de 2025 by Li, W., Chen, J., Li, J., Wang, S., Chen, Z., Zhao, L., Zhao, Y., Gu, L., Liu, J., Zhang, Y., Yang, X., Chen, T., Guo, Z.

Background
Chimeric antigen receptor (CAR)-T cell therapy has demonstrated remarkable success in hematologic malignancies; however, its efficacy in solid tumors remains limited. A major barrier is the immunosuppressive tumor microenvironment (TME), wh…