Li, Y., Li, Z., Tang, Y., Zhuang, X., Feng, W., Boor, P. P. C., Buschow, S., Sprengers, D., Zhou, G.

Unlocking the therapeutic potential of the NKG2A-HLA-E immune checkpoint pathway in T cells and NK cells for cancer immunotherapy

1 de November de 2024 by Li, Y., Li, Z., Tang, Y., Zhuang, X., Feng, W., Boor, P. P. C., Buschow, S., Sprengers, D., Zhou, G.

Immune checkpoint blockade, which enhances the reactivity of T cells to eliminate cancer cells, has emerged as a potent strategy in cancer therapy. Besides T cells, natural killer (NK) cells also play an indispensable role in tumor surveillance and de…