Ma, Y., Zhang, Q., Wei, Z., Zhou, Z., Wang, X., Xu, C., Liu, X., Min, S., Wang, P., Yuan, F., Jiao, Y., Yuan, G.

Glucose restriction reprograms lipid metabolism and enhances immunotherapy through ZNRF3-Wnt-SCD signaling axis

3 de June de 2026 by Ma, Y., Zhang, Q., Wei, Z., Zhou, Z., Wang, X., Xu, C., Liu, X., Min, S., Wang, P., Yuan, F., Jiao, Y., Yuan, G.

Background
Glucose restriction is a hallmark of the tumor microenvironment (TME), yet how tumor cells adapt to this metabolic stress and the impact of metabolic reprogramming on the TME remains incompletely understood.

Methods
A genome-wide CRISPR kn…