Qu, Z., Wang, Z., Hu, Y., Wei, X., Ding, W., Nomura, S., Guo, X., Feng, H., Zhang, Y., Gu, K.

TGF-{beta}1 drives neutrophil extracellular traps formation to promote CD8+ T cell exhaustion via the ERK-c-Fos-JunB axis, mediating gastric cancer immunotherapy resistance

4 de August de 2026 by Qu, Z., Wang, Z., Hu, Y., Wei, X., Ding, W., Nomura, S., Guo, X., Feng, H., Zhang, Y., Gu, K.

Background
Resistance to anti-programmed cell death protein-1 (PD-1) treatment in gastric cancer (GC) is closely associated with an immunosuppressive tumor microenvironment. However, the role of neutrophils in resistance to anti-PD-1 therapy remains u…