Ren, Y., Yu, X., Jiang, J., Luo, J., Zhao, C., Mao, X., Xi, Y., He, J., Yu, C., Hu, Y.

Streptococcus anginosus-associated kynurenic acid drives PD-1 blockade resistance through an ITGA2-mTOR-CTSV axis in gastric cancer

6 de August de 2026 by Ren, Y., Yu, X., Jiang, J., Luo, J., Zhao, C., Mao, X., Xi, Y., He, J., Yu, C., Hu, Y.

Background
The tumor microbiota critically shapes responses to immunotherapy; however, the mechanisms by which specific microbial species drive immune checkpoint blockade (ICB) resistance in gastric cancer (GC) remain poorly defined.

Methods
Streptoc…