Sun, F., Ma, F., Wang, T., Zhou, Y., Xu, D., Mo, H., Li, C., Guo, J., Zhao, Z., Yang, X., Zhong, N., Zhang, Y., Qian, H.

STS2 deficiency revives CD8+T cells from exhaustion and augments checkpoint blockade efficacy in cancer immunotherapy

23 de June de 2025 by Sun, F., Ma, F., Wang, T., Zhou, Y., Xu, D., Mo, H., Li, C., Guo, J., Zhao, Z., Yang, X., Zhong, N., Zhang, Y., Qian, H.

Background
T-cell exhaustion is a major barrier to effective antitumor immunity and limits the efficacy of cancer immunotherapies. This study investigates the role of suppressor of T-cell signaling 2 (STS2, also known as UBASH3A) in regulating CD8+ T-…