Wan, Y., Wang, J., Chen, M., Wang, J., Nan, F., Huang, H., Liu, Z., Hou, J.

Dual roles of IRE1{alpha} inhibition in reversing mitochondrial ROS-induced CD8+ T-cell senescence and exerting direct antitumor effects in multiple myeloma

27 de May de 2025 by Wan, Y., Wang, J., Chen, M., Wang, J., Nan, F., Huang, H., Liu, Z., Hou, J.

Background
Multiple myeloma (MM) is characterized by the proliferation of malignant plasma cells within the bone marrow (BM) microenvironment, which significantly contributes to immune suppression of CD8+ T cells. Our previous research identified that…