Wang, C., Liu, L., Zhang, J., Sun, S., Lv, X., Liu, Z., Zhou, L., Zhu, Z., Ni, H., Gu, C., Yang, Y.

Dexamethasone activates anti-tumor immunity in multiple myeloma by dismantling the GR-PPP1CB complex to restore STING/IRF3 signaling

23 de June de 2026 by Wang, C., Liu, L., Zhang, J., Sun, S., Lv, X., Liu, Z., Zhou, L., Zhu, Z., Ni, H., Gu, C., Yang, Y.

Background
The cyclic GMP-AMP synthase/stimulator of interferon genes (cGAS-STING) pathway mediates anti-tumor immunity by sensing cytosolic DNA and producing type I interferons, but is frequently suppressed in multiple myeloma (MM), enabling immune e…