Wang, J., Zhu, Y., He, X., Yin, S., He, Y., Yao, P., Li, J., Li, X., Shi, P., Qian, R., Xiao, Z., Ye, X., Xi, J. J., Ye, B.

Targeting non-canonical antigens unlocks functional T-cell responses in renal cell carcinoma

24 de June de 2026 by Wang, J., Zhu, Y., He, X., Yin, S., He, Y., Yao, P., Li, J., Li, X., Shi, P., Qian, R., Xiao, Z., Ye, X., Xi, J. J., Ye, B.

Background
Renal cell carcinoma (RCC) frequently exhibits favorable responses to immunotherapy, despite a low tumor mutational burden, suggesting a critical role for non-mutational antigens presented by human leukocyte antigen class I in activating CD…