Wang, K.-M., Zhang, L.-Z., Liang, J.-J., Wang, Z., Wang, X.-L., Zhang, J., Chen, G., Zhang, W.

ATF4 promotes immune evasion in oral squamous cell carcinoma by suppressing autophagic PD-L1 degradation

28 de May de 2026 by Wang, K.-M., Zhang, L.-Z., Liang, J.-J., Wang, Z., Wang, X.-L., Zhang, J., Chen, G., Zhang, W.

Background
Immune checkpoint blockade targeting programmed death-1/programmed death-ligand 1 (PD-1/PD-L1) has revolutionized cancer therapy. However, its efficacy is frequently limited by primary and acquired resistance. While inflammatory signals tra…