Wang, L., Yang, G., Lei, H., Zhang, Y., Li, B., Liu, M., Huang, Y., Chen, X., Tai, P., Pan, Z.

CSF proteomics identifies ADGRG1 as a predictive biomarker of intrathecal immune checkpoint inhibitor response in leptomeningeal metastasis

19 de February de 2026 by Wang, L., Yang, G., Lei, H., Zhang, Y., Li, B., Liu, M., Huang, Y., Chen, X., Tai, P., Pan, Z.

Background
Leptomeningeal metastasis (LM) is a fatal complication of advanced cancer with limited therapeutic options and poor prognosis. Immune checkpoint inhibitors (ICIs) have shown promise in systemic disease, but intrathecal ICIs efficacy and imm…