Wang, Y., Peng, C., Feng, S., Wen, S., Xu, C., Du, X., Jiang, W., Zou, R., Shi, Y., Ma, Y., Xu, Z., Jiang, M., Shen, B.

PGE2-mediated NK cell reprogramming drives acquired immunotherapy resistance in lung adenocarcinoma

12 de August de 2026 by Wang, Y., Peng, C., Feng, S., Wen, S., Xu, C., Du, X., Jiang, W., Zou, R., Shi, Y., Ma, Y., Xu, Z., Jiang, M., Shen, B.

Background
Acquired resistance limits the durability of programmed cell death protein-1 (PD-1) blockade in lung adenocarcinoma, yet the tumor-intrinsic programs and immune circuits that drive acquired resistance relapse remain poorly defined. The purp…