Wu, J., Liu, N., Chen, J., Tao, Q., Lu, C., Li, Q., Chen, X., Peng, C.

Clofarabine induces tumor cell apoptosis, GSDME-related pyroptosis, and CD8+ T-cell antitumor activity via the non-canonical P53/STING pathway

6 de February de 2025 by Wu, J., Liu, N., Chen, J., Tao, Q., Lu, C., Li, Q., Chen, X., Peng, C.

Background
Clofarabine (Clo) is a Food and Drug Administration (FDA)-approved drug for the treatment of acute lymphoblastic leukemia; however, its effects on solid tumors remain largely unknown.

Methods
In vitro and in vivo experiments have demonstra…