Wu, J., Zhu, S., Zang, G., Wang, H., Yang, N., Qiao, Y., Wei, Q., Wang, L., Ren, Z., Liu, Y.-J., Chen, J.

CPT1A inhibition alleviates plasmacytoid dendritic cell-mediated immune suppression in colon cancer through fatty acid oxidation modulation

24 de October de 2025 by Wu, J., Zhu, S., Zang, G., Wang, H., Yang, N., Qiao, Y., Wei, Q., Wang, L., Ren, Z., Liu, Y.-J., Chen, J.

Background
The tolerization of plasmacytoid dendritic cells (pDCs) within the tumor microenvironment facilitates immune evasion, thereby significantly limiting the efficacy of cancer immunotherapy. Metabolic regulators are crucial in determining immun…