Xiao, Q., Zhang, X., Liang, X., Yu, G., Li, Y., Du, R., Xiang, H., Yang, Z., Liu, Y.

This Highlight describes a key observation where serotonin transporter (SERT) was shown to suppress CD8+ T cell antitumor responses via depletion of intratumoral 5-HT. While selective serotonin reuptake inhibitors (SSRIs)—among the most widely u…