TGF-{beta} trap of AdAPT-001 turns up the heat on tumors and turns down checkpoint blocker resistance

At the ASCO 2024 meeting, Anthony P Conley, coauthor on this editorial, presented promising data from the phase 1/2 clinical trial called BETA PRIME (ClinicalTrials.gov NCT04673942) with AdAPT-001 plus a checkpoint inhibitor (CI). All participants gav…

Impact of Helicobacter pylori on immunotherapy in gastric cancer

This study reviews the contrasting finding regarding the impact of Helicobacter pylori infection on the efficacy of immunotherapy in gastric cancer (GC). While a large retrospective study reported a positive association between H. pylori infection and…

scRNA+ TCR-seq revealed dual TCR T cells antitumor response in the TME of NSCLC

The intricate origins, subsets, and characteristics of TCR (T Cell Receptor) s, along with the mechanisms underpinning the antitumor response of tumor-infiltrating T lymphocytes within the tumor microenvironment (TME) remain enigmatic. Recently, the a…

Merkel cell carcinoma refractory to anti-PD(L)1: utility of adding ipilimumab for salvage therapy

Merkel cell carcinoma (MCC) incidence has risen to approximately 3,000 cases annually in the USA. Although anti-programmed cell death (ligand) 1 (PD-(L)1) agents are now the first-line treatment for advanced MCC, approximately 50% of such patients do …

Acknowledging and addressing real-world challenges to treating immune-related adverse events

Immune checkpoint inhibitors (ICIs) have revolutionized oncology treatment. However, their success is mitigated by the recognition that ICI-induced immune-related adverse events (irAEs) pose considerable challenges to patients and clinicians. These au…

Osteoporotic fractures: an unrecognized adverse event of immune checkpoint inhibitors?

The widespread use of immune checkpoint inhibitors (ICIs) in clinical practice has broadened our understanding of their immune-related adverse events (irAEs). IrAEs, including musculoskeletal adverse events, remain a significant concern. While ICI-ass…

Hypothesis: the generation of T cells directed against neoepitopes employing immune-mediating agents other than neoepitope vaccines

The development of vaccines, especially RNA-based, directed against patient-specific tumor neoepitopes is an active and productive area of cancer immunotherapy. Promising clinical results in melanoma and other solid tumor types are emerging. As with a…

deneme bonusu veren siteler - canlı bahis siteleri - casino siteleri casino siteleri deneme bonusu veren siteler canlı casino siteleri https://lookerstudio.google.com/reporting/ed110eb0-b9fd-4c6b-9b4b-3447fe8188a6/page/QJeNE https://elementorpro-nulled.tumblr.com/post/766616316533669889/yoast-seo-premium-nulled-download-all-version